Answers Book · DHM
What Are DHM Side Effects?
The 10-second answer
There is no established complete side-effect profile for DHM used after drinking.
The simple answer
Not knowing all the risks is different from knowing there are none. Early studies cannot show every possible problem in people. If you feel unwell after a supplement, do not dismiss it because the label calls it natural.
Myth vs Fact
Myth
No widely known side effects means no side effects.
Fact
Missing safety information is not proof of safety.
The science
- ClinicalTrials.govThe registered Phase I DHM study is designed to assess adverse events and how purified DHM moves through the body. A registration is not a completed safety result.
- Shen et al. 2012The Shen study tested rats and cultured neurons; it cannot establish a human side-effect profile.
- NIH / NCCIHNCCIH advises reporting serious suspected supplement reactions and talking with health care providers about supplement use.
Medical sources
- ClinicalTrials.gov, NCT05623501↗Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease. Trial registration (study plan, not results).
- Shen et al. (2012), Journal of Neuroscience↗Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication. Research paper hosted on PubMed Central.
- NIH / NCCIH↗Using Dietary Supplements Wisely
How often people ask
How often people ask: Low - qualitative PAA-based estimate, not measured search volume.
Keep reading
← All questions in the Answers BookThis page is general information, not medical advice. Sources are linked above. If you're worried about yourself or someone else, contact a healthcare provider or call 911.
Last checked: October 8, 2026